ACD856
Category: nootropics
Mentions
MScreenshot 2026-06-16 at 20.14.25.png.txt
https://x.com/doctormorphh/status/2046467515418617 (approx.)
At 28 you can literally learn anything you want and plasticity is thriving, especially the type of plasticity you need to learn new things.
if you want to improve plasticity:
Avoid smoking
Gut health
BPN14770
Pinealon
Magtein
ACD856
Bacopa monnieri
Intranasal Insulin
Learn new things constantly; languages, skills, chess, ...
Its important to combine all these tools with learning like the way one should combine steroids with training.
You will literally have child like learning again.
[Image shows Bradley Cooper as NZT48/Limitless movie character]
12:44 PM · Jun 10, 2026 · 23.7K Views
Compounds: BPN14770, pinealon, magtein (magnesium L-threonate), ACD856, Bacopa monnieri, intranasal insulin
At 28 you can literally learn anything you want and plasticity is thriving, especially the type of plasticity you need to learn new things.
if you want to improve plasticity:
Avoid smoking
Gut health
BPN14770
Pinealon
Magtein
ACD856
Bacopa monnieri
Intranasal Insulin
Learn new things constantly; languages, skills, chess, ...
Its important to combine all these tools with learning like the way one should combine steroids with training.
You will literally have child like learning again.
[Image shows Bradley Cooper as NZT48/Limitless movie character]
12:44 PM · Jun 10, 2026 · 23.7K Views
Compounds: BPN14770, pinealon, magtein (magnesium L-threonate), ACD856, Bacopa monnieri, intranasal insulin
BScreenshot 2026-06-17 at 21.47.45.png.txt
stuff i have coming in right now: bemethyl, tesofensine, BAM-15, dihexa, pregnenolone, thiamine TTFD, saltorexant, tak-653, vesugen, vilon, nsi-189, pri-8-53, gb-115, acd856, coluracetam
Anyone tried ACD856, TAK-653 or BPN14770?
ACD856 (Trk/BDNF positive allosteric modulator): ~10mg/day, user reported tripled motivation/mood, reduced rumination/anxiety, lightness and focus; effects faded toward subtle after ~a month; cycle it. Source: Everychem.
TAK-653 (AMPA modulator): used for weeks, zero side effects, better mood and focus especially stacked with Semax and Bromantane; good non-stimulant ADHD option; timing not critical.
BPN14770 (PDE4D inhibitor): ~40-90mg once or twice daily, no insomnia/stimulant feel, but no clear recall/memory benefit vs racetams for one user.
Compounds: ACD856, TAK-653, BPN14770, Semax, Bromantane
ACD856 (Trk/BDNF positive allosteric modulator): ~10mg/day, user reported tripled motivation/mood, reduced rumination/anxiety, lightness and focus; effects faded toward subtle after ~a month; cycle it. Source: Everychem.
TAK-653 (AMPA modulator): used for weeks, zero side effects, better mood and focus especially stacked with Semax and Bromantane; good non-stimulant ADHD option; timing not critical.
BPN14770 (PDE4D inhibitor): ~40-90mg once or twice daily, no insomnia/stimulant feel, but no clear recall/memory benefit vs racetams for one user.
Compounds: ACD856, TAK-653, BPN14770, Semax, Bromantane
You shouldnt use semax for cognition, at all.
People love to mention its effect on BDNF for plasticity but there are a hundred things that are better than semax that still affect BDNF.
Good news: there is A TON of better shit waiting on you.
> NSI-189
> J-147
> BPN14770
> Eutropoflavin
> Bryostatin-1
> Cerebrolysin
> Safinamide
> ACD856
Even naturals like resveratrol and rhodolia rosea would overall, looking at the bigger picture and not solely BDNF, be better than semax.
Studies on semax saw no increase in dopamine on its own, but did see potentiated dopamine release when semax was combined with d-amphetamine. Which is where it potentially could be used.
Not to mention the dosage it should be taken at for its BDNF effects are around 500-2500mg intranasally which is probably way above what you are currently taking it.
Here's my bottom line; if you like semax, good.
There are SO MANY nootropics that can largely do what it does and much more than that, so you have a ton of amazing options to pick from.
[reply] It heavily potentiates the dopamine response.
Compounds: Semax, NSI-189, J-147, BPN14770, Eutropoflavin, Bryostatin-1, Cerebrolysin, Safinamide, ACD856, Resveratrol, Rhodiola rosea, d-amphetamine
People love to mention its effect on BDNF for plasticity but there are a hundred things that are better than semax that still affect BDNF.
Good news: there is A TON of better shit waiting on you.
> NSI-189
> J-147
> BPN14770
> Eutropoflavin
> Bryostatin-1
> Cerebrolysin
> Safinamide
> ACD856
Even naturals like resveratrol and rhodolia rosea would overall, looking at the bigger picture and not solely BDNF, be better than semax.
Studies on semax saw no increase in dopamine on its own, but did see potentiated dopamine release when semax was combined with d-amphetamine. Which is where it potentially could be used.
Not to mention the dosage it should be taken at for its BDNF effects are around 500-2500mg intranasally which is probably way above what you are currently taking it.
Here's my bottom line; if you like semax, good.
There are SO MANY nootropics that can largely do what it does and much more than that, so you have a ton of amazing options to pick from.
[reply] It heavily potentiates the dopamine response.
Compounds: Semax, NSI-189, J-147, BPN14770, Eutropoflavin, Bryostatin-1, Cerebrolysin, Safinamide, ACD856, Resveratrol, Rhodiola rosea, d-amphetamine