Deworming Protocol
Antiparasitic clearance using ivermectin, fenbendazole, and/or mebendazole. Frequently recommended as a first step before the full Gut Reset Protocol — clearing parasites before addressing bacteria and fungi avoids fighting on multiple fronts simultaneously.
Part of the Gut Reset
This is a sub-protocol of the Gut Reset Protocol. S. Boulardii must be run throughout the entire deworming phase to protect native gut flora from the kill phase.
Hepatic load — read before stacking
Ivermectin and the benzimidazoles are all cleared by the liver, and running them daily for weeks is a sustained processing load — amplified if you stack other drugs through the same CYP3A4 pathway. Do not double up fenbendazole and mebendazole (same mechanism → double the liver load for zero extra parasites killed — pick one). Lower-and-shorter dosing, pulsing, dropping alcohol/grapefruit, stocking Phase II support (NAC/glutathione, glycine, taurine, TUDCA), and baseline + periodic liver bloods (ALT/AST) are how you keep it safe. See the Hepatic Load deep dive for the full mechanism.
The Core Stack
Three compounds appear across virtually every protocol in the tweets:
| Compound | What it is | Mechanism |
|---|---|---|
| Ivermectin | Antiparasitic drug, also antiprotozoal | Disrupts parasite nervous system; inhibits cancer signalling pathways (Akt, Wnt, mTOR) as a side effect; half-life 18h, cleared in 2 days |
| Fenbendazole | Veterinary dewormer (dog/horse). Generic: ~$1/pill | Disrupts microtubules → stops cell division. Same mechanism as taxol (cancer chemotherapy). Discovered accidentally by Joe Tippens 2017 |
| Mebendazole | FDA-approved human equivalent of fenbendazole (brand: Vermox) | Virtually identical mechanism to fenbendazole. Preferred if you want pharmaceutical-grade |
Fenbendazole and Mebendazole are interchangeable mechanically — mebendazole is the regulated human version, fenbendazole is the cheaper veterinary version. Most protocols pick one.
Dosing Referenced in Tweets
General gut/wellness (non-cancer)
| Compound | Dose | Source |
|---|---|---|
| Ivermectin | ~0.2–0.4 mg/kg | Community consensus |
| Fenbendazole | 444–500 mg/day | skymeds_store · Valerie Anne Smith |
| Mebendazole | 500 mg/day | Valerie Anne Smith |
Ivermectin dose tiers (DrJackKruse · anabology)
| Level | Dose |
|---|---|
| Low | 0.1 mg/kg |
| Medium | 1.0 mg/kg |
| High | 3.0 mg/kg |
Cancer protocol doses (reference only)
| Compound | Low grade | High grade |
|---|---|---|
| Fenbendazole | 1 mg/kg | 5–10 mg/kg |
| Mebendazole | 1 mg/kg | 50–100 mg/kg |
| Ivermectin | 0.1 mg/kg | 3.0 mg/kg |
Personal Reports from Tweets
Valerie Anne Smith — 7-week protocol, 500mg Mebendazole + Ivermectin daily:
"Days 1–10: barely noticed anything. Week 2: waking up before alarm naturally. Week 3: bloating basically gone. Digestion feels cleaner, energy stable throughout the day, brain fog noticeably improved. People around me started commenting I looked more awake before I even mentioned what I was taking."
skymeds_store — therapeutic doses (72mg IVM + 444mg FBZ), cancer context:
"My sleep fixed itself. I wake up without an alarm. I don't crave sugar anymore. I don't even want to over-eat. I feel… calm."
Critical: Flora Protection During Kill Phase
Ben Smith + reply from Reliable Chemist (@jwengen_post):
"S. boulardii (CNCM I-745 strain, 250mg 2×/day) is the ONLY probiotic I trust during Ivermectin/fenben/antibiotic protocols. It's a yeast, not a bacterium — it survives the kill phase, blocks Candida overgrowth that often follows antiparasitic treatment, and protects native flora. Pair with VSL#3 timed 4h apart for full rebuild."
This is non-optional. Antiparasitic drugs do not discriminate — they alter the gut environment significantly. Without S. Boulardii, candida overgrowth commonly fills the vacuum left by the killed organisms.
Joe Tippens Stack (viral cancer case, 2017)
The protocol that launched mainstream awareness of fenbendazole. Joe Tippens, Stage 4 small cell lung cancer, sent home to die — full remission attributed to:
- Fenbendazole (veterinary dewormer)
- Curcumin
- CBD oil
- Vitamin E
Referenced by DrJackKruse and anabology. Now has a 110,000-member Facebook support group.
Turpentine (Alternative/Adjunct)
Victor Scott advocates pure gum spirits of turpentine as an antiparasitic with biofilm-disrupting properties:
"Turpentine causes parasites in the body to flee to the exit. It also removes biofilm."
Reported improvement in autistic children's ATEC scores in 3 months. Highly controversial — pure gum spirits only, strict protocol required. Research independently before attempting.
Protocol Summary
- Ivermectin ~0.2–0.4 mg/kg
- Fenbendazole 444–500mg/day OR Mebendazole 500mg/day
- S. Boulardii (Florastor CNCM I-745) 250mg 2×/day — start day 1, run throughout
- VSL#3 broad-spectrum probiotic — timed 4h apart from S. Boulardii
- Pair with Vitamin C (4000mg), fasting periods, low-inflammatory diet
- Duration: 3–8 weeks typical in community reports
After deworming, move to the full Gut Reset Protocol — kill remaining bacteria/fungi, break biofilm, clear endotoxins, repair lining, repopulate flora.
All information compiled from biohacking Twitter discussions. Educational purposes only. Not medical advice. These compounds require medical supervision.