Glutathione
Category: amino_acids
Mentions
Glycine + NAC reverse nearly all signs of aging + metabolic disease in 2 weeks. [study]
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
- Toxin binding (endotoxins, mycotoxins): S Boulardii
- Gut-brain support (mood, neurotransmitters, neuroinflammation): S Boulardii
- Candida (antifungal, anti-biofilm): S Boulardii
- SIBO control: S Boulardii
- H. pylori defence: S Boulardii
- Leaky gut repair: S Boulardii
- Immune modulation (↓ inflam, ↑ IgA): S Boulardii
- Bile support by reduce LPS: S Boulardii
- Improve glutathione production: S Boulardii
[Reply from Isaac @BasketNet01 - Mar 12, 2025: Been on the Saccharomyces 108 - Saccharomyces Boulardii for over a month now. Reduction in generated anxiety. IIM are regular and unmm solid. Overall comprehension at work is much improved. Increased energy at work. Thanks for putting me into it. You're a credit to society]
12:37 AM · Mar 12, 2025 · 327.3K Views
Compounds: S. Boulardii (Saccharomyces boulardii), glutathione, IgA, LPS
- Gut-brain support (mood, neurotransmitters, neuroinflammation): S Boulardii
- Candida (antifungal, anti-biofilm): S Boulardii
- SIBO control: S Boulardii
- H. pylori defence: S Boulardii
- Leaky gut repair: S Boulardii
- Immune modulation (↓ inflam, ↑ IgA): S Boulardii
- Bile support by reduce LPS: S Boulardii
- Improve glutathione production: S Boulardii
[Reply from Isaac @BasketNet01 - Mar 12, 2025: Been on the Saccharomyces 108 - Saccharomyces Boulardii for over a month now. Reduction in generated anxiety. IIM are regular and unmm solid. Overall comprehension at work is much improved. Increased energy at work. Thanks for putting me into it. You're a credit to society]
12:37 AM · Mar 12, 2025 · 327.3K Views
Compounds: S. Boulardii (Saccharomyces boulardii), glutathione, IgA, LPS
If you look at a lot of the cases of H. pylori and its link to cancer
It's less about the bacteria being the direct cause of the cancer and more so about what it's doing to your endogenous antioxidants like SOD and glutathione
(It depletes glutathione)
For context, it shifts your redox environment toward oxidative damage.
And this is what likely contributes to carcinogenesis through DNA injury, lipid peroxidation, and impaired antioxidant defenses
And the evidence is there.
Both human and cell studies show lower glutathione in infected gastric tissue, alongside altered an SOD/catalase activity and higher oxidative stress markers
The sooner you understand the delicate balance between oxidative stress and antioxidants, the better
It's a seesaw.
Compounds: glutathione, superoxide dismutase (SOD) — H. pylori / oxidative carcinogenesis
It's less about the bacteria being the direct cause of the cancer and more so about what it's doing to your endogenous antioxidants like SOD and glutathione
(It depletes glutathione)
For context, it shifts your redox environment toward oxidative damage.
And this is what likely contributes to carcinogenesis through DNA injury, lipid peroxidation, and impaired antioxidant defenses
And the evidence is there.
Both human and cell studies show lower glutathione in infected gastric tissue, alongside altered an SOD/catalase activity and higher oxidative stress markers
The sooner you understand the delicate balance between oxidative stress and antioxidants, the better
It's a seesaw.
Compounds: glutathione, superoxide dismutase (SOD) — H. pylori / oxidative carcinogenesis