Glutathione
Category: amino_acids
Mentions
Glycine + NAC reverse nearly all signs of aging + metabolic disease in 2 weeks. [study]
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
- Toxin binding (endotoxins, mycotoxins): S Boulardii
- Gut-brain support (mood, neurotransmitters, neuroinflammation): S Boulardii
- Candida (antifungal, anti-biofilm): S Boulardii
- SIBO control: S Boulardii
- H. pylori defence: S Boulardii
- Leaky gut repair: S Boulardii
- Immune modulation (↓ inflam, ↑ IgA): S Boulardii
- Bile support by reduce LPS: S Boulardii
- Improve glutathione production: S Boulardii
[Reply from Isaac @BasketNet01 - Mar 12, 2025: Been on the Saccharomyces 108 - Saccharomyces Boulardii for over a month now. Reduction in generated anxiety. IIM are regular and unmm solid. Overall comprehension at work is much improved. Increased energy at work. Thanks for putting me into it. You're a credit to society]
12:37 AM · Mar 12, 2025 · 327.3K Views
Compounds: S. Boulardii (Saccharomyces boulardii), glutathione, IgA, LPS
- Gut-brain support (mood, neurotransmitters, neuroinflammation): S Boulardii
- Candida (antifungal, anti-biofilm): S Boulardii
- SIBO control: S Boulardii
- H. pylori defence: S Boulardii
- Leaky gut repair: S Boulardii
- Immune modulation (↓ inflam, ↑ IgA): S Boulardii
- Bile support by reduce LPS: S Boulardii
- Improve glutathione production: S Boulardii
[Reply from Isaac @BasketNet01 - Mar 12, 2025: Been on the Saccharomyces 108 - Saccharomyces Boulardii for over a month now. Reduction in generated anxiety. IIM are regular and unmm solid. Overall comprehension at work is much improved. Increased energy at work. Thanks for putting me into it. You're a credit to society]
12:37 AM · Mar 12, 2025 · 327.3K Views
Compounds: S. Boulardii (Saccharomyces boulardii), glutathione, IgA, LPS