NAC (N-Acetylcysteine)
Category: amino_acids
Mentions
Glycine + NAC reverse nearly all signs of aging + metabolic disease in 2 weeks. [study]
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
The two synergize to improve glutathione production, for some incredible results:
◆ Glutathione synthesis rate ↑ -120%
◆ Total glutathione ↑ ~50%
◆ GSH/GSSG ratio ↑ ~125%
◆ Plasma reactive oxygen metabolites ↓ ~50%
◆ Plasma F2-isoprostanes (oxidative stress) ↓ ~35%
It also improved oxidative metabolism:
◆ Fasted NEFA oxidation ↑ ~50%
◆ Fed NEFA oxidation ↑ ~70%
◆ Fed carbohydrate oxidation ↑ ~20%
◆ Suppression of NEFA oxidation (fed vs fasted) ↑ ~135%
◆ Stimulation of carbohydrate oxidation (fed vs fasted) ↑ ~690%
◆ Insulin sensitivity index ↑ ~35%
AND body composition:
◆ Fat mass: 21.6 → 20.0 kg
◆ Fat-free mass: 60.1 → 61.0 kg
◆ Muscle strength (dominant arm): 35 → 37
◆ Muscle strength (nondominant arm): 31 → 34
They did do megadoses - 9g NAC + 7g glycine, but a lower daily maintenance dose would work as well.
[Graph showing glycine + NAC vs placebo results across oxidative stress and metabolic markers]
Compounds: glycine, NAC (N-acetylcysteine), glutathione, NEFA
If you're experiencing pain and bloating in your gut every time you eat, this is a supplement stack you can try:
1. Curcumin mervia (1000mg twice daily)
2. NAC (1000mg twice daily)
3. Glycine (5-10g daily)
4. Black seed oil (60 mins post meal)
5. S Boulardii (1 tab 60 mins post meal)
Food wise, try either
1. Low starch, or
2. Low FODMAP
To aid other potential issues with digestion, try:
1. ACV (diluted) before food
2. Try betaine HCL with food (start low dose)
3. Try one 250-500mg TUDCA with food
4. Try digestive enzymes with food
And take out any bigger triggers like gluten.
If the above isn't enough to improve symptoms, you may need to look much deeper.
Have you tried something like this? Did it help?
10:37 PM · Nov 26, 2025 · 213K Views
Compounds: curcumin (Meriva), NAC, glycine, black seed oil, S. Boulardii, ACV (apple cider vinegar), betaine HCL, TUDCA, digestive enzymes
1. Curcumin mervia (1000mg twice daily)
2. NAC (1000mg twice daily)
3. Glycine (5-10g daily)
4. Black seed oil (60 mins post meal)
5. S Boulardii (1 tab 60 mins post meal)
Food wise, try either
1. Low starch, or
2. Low FODMAP
To aid other potential issues with digestion, try:
1. ACV (diluted) before food
2. Try betaine HCL with food (start low dose)
3. Try one 250-500mg TUDCA with food
4. Try digestive enzymes with food
And take out any bigger triggers like gluten.
If the above isn't enough to improve symptoms, you may need to look much deeper.
Have you tried something like this? Did it help?
10:37 PM · Nov 26, 2025 · 213K Views
Compounds: curcumin (Meriva), NAC, glycine, black seed oil, S. Boulardii, ACV (apple cider vinegar), betaine HCL, TUDCA, digestive enzymes
When treating the gut, start with THIS check list:
1. Have you address inflammation (diet and life changes first, then metabolic or weight issues, and if need support meriva curcumin + boswellia, or even peptides like KPV)
2. Have you address digestion
- stomach acid via sufficient zinc, swedish bitters or arugula
- bile support via taurine, glycine, folate, B2, choline and b12
- iberogast/magnesium citrate if constipated
- digestive enzymes if low on test, have thyroid issues, or can't digest fats + starch
- trialled removing FODMAPs: starch, or other trigger foods – may need an elimination diet
3. Are you supporting any immune issue?
- may need to inhibit mast cell degranulation (boswellia, PEA, black seed oil, passionflower)
- support break down of histamine (via methylation nutrients, vitamin C, copper, DAO)
- elimination diet sometimes
4. Does your motility need support?
- if constipation (kiwi, iberagast, mg citrate, PHGG)
- if diarrhea (PHGG, fibre/starch in food as can tolerate)
5. Do you need to oxidative stress
- fruits and pomegranate juice as tolerated
- NAC with selenium and molybdenum
- black seed oil
6. Ensure you support the gut lining
- bone broth, collagen, glycine, gelatin
- zinc l carnosine
- s boulardii
- glutamine,
- peptides like BPC-157, larazotide, GHK or TBC500
- foods like okra and resistant starch as tolerated
7. Other factors
- sleep
- moderate exercise
- 10% calorie deficit but nutrient excess
- proper light environment practices and sufficient sunlight
- check cronometer for nutrients you're hitting, supplement what you aren't
- walk lots
- meditate or pray
This is a spring board to then work into your microbial/biofilm issues [truncated]
Compounds: curcumin (Meriva), boswellia, KPV peptide, zinc, taurine, glycine, folate, choline, magnesium citrate, PEA (palmitoylethanolamide), black seed oil, NAC, selenium, molybdenum, collagen, gelatin, zinc L-carnosine, S. boulardii, glutamine, BPC-157, larazotide, GHK, TBC500, vitamin C, copper, DAO
1. Have you address inflammation (diet and life changes first, then metabolic or weight issues, and if need support meriva curcumin + boswellia, or even peptides like KPV)
2. Have you address digestion
- stomach acid via sufficient zinc, swedish bitters or arugula
- bile support via taurine, glycine, folate, B2, choline and b12
- iberogast/magnesium citrate if constipated
- digestive enzymes if low on test, have thyroid issues, or can't digest fats + starch
- trialled removing FODMAPs: starch, or other trigger foods – may need an elimination diet
3. Are you supporting any immune issue?
- may need to inhibit mast cell degranulation (boswellia, PEA, black seed oil, passionflower)
- support break down of histamine (via methylation nutrients, vitamin C, copper, DAO)
- elimination diet sometimes
4. Does your motility need support?
- if constipation (kiwi, iberagast, mg citrate, PHGG)
- if diarrhea (PHGG, fibre/starch in food as can tolerate)
5. Do you need to oxidative stress
- fruits and pomegranate juice as tolerated
- NAC with selenium and molybdenum
- black seed oil
6. Ensure you support the gut lining
- bone broth, collagen, glycine, gelatin
- zinc l carnosine
- s boulardii
- glutamine,
- peptides like BPC-157, larazotide, GHK or TBC500
- foods like okra and resistant starch as tolerated
7. Other factors
- sleep
- moderate exercise
- 10% calorie deficit but nutrient excess
- proper light environment practices and sufficient sunlight
- check cronometer for nutrients you're hitting, supplement what you aren't
- walk lots
- meditate or pray
This is a spring board to then work into your microbial/biofilm issues [truncated]
Compounds: curcumin (Meriva), boswellia, KPV peptide, zinc, taurine, glycine, folate, choline, magnesium citrate, PEA (palmitoylethanolamide), black seed oil, NAC, selenium, molybdenum, collagen, gelatin, zinc L-carnosine, S. boulardii, glutamine, BPC-157, larazotide, GHK, TBC500, vitamin C, copper, DAO