Citicoline (CDP-Choline)
Category: nootropics
Mentions
The 80/20 cognitive enhancement stack that hits hard as FUCK with zero tolerance buildup and zero waste:
- 150 mg armodafinil (cleaner pharmacokinetics than modafinil, longer-lasting wakefulness + deep focus)
- 250 mg citicoline (replenish the depleted stores of the vital neurotransmitter acetylcholine from armodafinil depletion)
- 200 mg caffeine (extra kick, focus, capsule form or just bang black coffee/ espressos all day long)
- 800 mg l-theanine (takes the edge off the stimulating compounds, calm + creative)
- 144 mg magnesium l-threonate (optimizes cognitive health by crossing BBB, helps with sleep quality)
- 2 mg oral pinealon (obliterates brain fog, heightens stress-resistance + focus, helps you sleep deeper)
- 6 mg oral epitalon (resets circadian rhythm despite long-lasting armodafinil, lowers cortisol, amazing for longevity)
you could run this 5 days on, 2 days off pretty much indefinitely without building a tolerance. cycle pinealon and epitalon 30 days on -> 2 months off, then continue as you please.
epitalon in the evening, everything else in the morning (magnesium can also be taken in the evening, but i prefer morning). if you need to prioritize due to $ constraints, remove epi + pine first. honorary mention tadalafil. honorary mention do a damn blood panel and fix whatever is bad first. not medical advice.
sources below, US domestic here. more in this doc (incl. EU, aus etc.): basedbiohacker.any.org/cognitive-enha...
armodafinil: modafinlxl.com/buy/waklert-do...
pinealon: yourprotocol.co/products/pinea...
epitalon: yourprotocol.co/products/epita...
magnesium l-threonate: nootropicsdepot.com/magtein-magnes...
citicoline: nootropicsdepot.com/cognizin-citic...
l-theanine: nootropicsdepot.com/L-theanine-cap...
Compounds: armodafinil, citicoline, caffeine, l-theanine, magnesium l-threonate, pinealon, epitalon, tadalafil
- 150 mg armodafinil (cleaner pharmacokinetics than modafinil, longer-lasting wakefulness + deep focus)
- 250 mg citicoline (replenish the depleted stores of the vital neurotransmitter acetylcholine from armodafinil depletion)
- 200 mg caffeine (extra kick, focus, capsule form or just bang black coffee/ espressos all day long)
- 800 mg l-theanine (takes the edge off the stimulating compounds, calm + creative)
- 144 mg magnesium l-threonate (optimizes cognitive health by crossing BBB, helps with sleep quality)
- 2 mg oral pinealon (obliterates brain fog, heightens stress-resistance + focus, helps you sleep deeper)
- 6 mg oral epitalon (resets circadian rhythm despite long-lasting armodafinil, lowers cortisol, amazing for longevity)
you could run this 5 days on, 2 days off pretty much indefinitely without building a tolerance. cycle pinealon and epitalon 30 days on -> 2 months off, then continue as you please.
epitalon in the evening, everything else in the morning (magnesium can also be taken in the evening, but i prefer morning). if you need to prioritize due to $ constraints, remove epi + pine first. honorary mention tadalafil. honorary mention do a damn blood panel and fix whatever is bad first. not medical advice.
sources below, US domestic here. more in this doc (incl. EU, aus etc.): basedbiohacker.any.org/cognitive-enha...
armodafinil: modafinlxl.com/buy/waklert-do...
pinealon: yourprotocol.co/products/pinea...
epitalon: yourprotocol.co/products/epita...
magnesium l-threonate: nootropicsdepot.com/magtein-magnes...
citicoline: nootropicsdepot.com/cognizin-citic...
l-theanine: nootropicsdepot.com/L-theanine-cap...
Compounds: armodafinil, citicoline, caffeine, l-theanine, magnesium l-threonate, pinealon, epitalon, tadalafil
running this interesting stack for the coming 4-8 weeks or so:
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
If you want autistic cognition without tweaking like you took some 99% Walter White special the stack would look something like:
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
BScreenshot 2026-06-17 at 21.48.33.png.txt
S TIER: citicoline: directly supporting acetylcholine production and membrane integrity for memory and focus