Guanfacine
Category: nootropics
Mentions
i LOVE guanfacine because it can increase mental capacity and output while being the EXACT opposite of a stimulant
instead of making the brain a clusterfuck it decreases firing making you calm and clear headed instead of all over the place
- calm focus
- better working memory
- "zen" flow state
- better mental resilience to stress
- no hyperactivity
- less distraction
how the fuck does it do that since it literally decreases neural signaling?
guanfacine is a selective agonist of the α2A receptor, a receptor located primarily in the prefrontal cortex which could be named the "control center of mental performance".
activation of α2A by guanfacine results in less intracellular cascades going on that would normally make you stimulated.
it makes your brain less noisy so that you can think. clearly.
now you need to get the dosing right because it can be sedative at higher doses. anywhere in between 1-2mg is enough.
the benefit of this is that you can take it in the evening and fall asleep with no issues, with anything you can take it right before bed since it can be sedative at doses higher than 4mg.
not medical advice. of course.
Compounds: guanfacine
instead of making the brain a clusterfuck it decreases firing making you calm and clear headed instead of all over the place
- calm focus
- better working memory
- "zen" flow state
- better mental resilience to stress
- no hyperactivity
- less distraction
how the fuck does it do that since it literally decreases neural signaling?
guanfacine is a selective agonist of the α2A receptor, a receptor located primarily in the prefrontal cortex which could be named the "control center of mental performance".
activation of α2A by guanfacine results in less intracellular cascades going on that would normally make you stimulated.
it makes your brain less noisy so that you can think. clearly.
now you need to get the dosing right because it can be sedative at higher doses. anywhere in between 1-2mg is enough.
the benefit of this is that you can take it in the evening and fall asleep with no issues, with anything you can take it right before bed since it can be sedative at doses higher than 4mg.
not medical advice. of course.
Compounds: guanfacine
you can just take noots and stims and be smarter than everyone else
- modafinil (wakefulness + focus)
- cerebrolysin (recovery + cognition)
- crebinostat (literal photographic memory)
- piracetam
- IN insulin (cognition + recovery)
- dextroamphetamine (focus + memory)
- pinealon (recovery + sleep)
- tropisetron (calm focus)
- TAK-653
- guanfacine (non-stim)
- Chlorgyline (MAO-A)
- Usmarapride (memory)
- KW-6365
- Dihexa (low dose - recovery)
- bromantane
- CE-123 (modafinil analogue)
- methylphenidate (focus)
- Menthol (anxiolytic)
the list could go on
life is not a drug tested sport - if you dont enhance yourself your competition will and you will get left behind
Compounds: modafinil, cerebrolysin, crebinostat, piracetam, intranasal insulin, dextroamphetamine, pinealon, tropisetron, TAK-653, guanfacine, Chlorgyline, usmarapride, KW-6365, Dihexa, bromantane, CE-123, methylphenidate, menthol
- modafinil (wakefulness + focus)
- cerebrolysin (recovery + cognition)
- crebinostat (literal photographic memory)
- piracetam
- IN insulin (cognition + recovery)
- dextroamphetamine (focus + memory)
- pinealon (recovery + sleep)
- tropisetron (calm focus)
- TAK-653
- guanfacine (non-stim)
- Chlorgyline (MAO-A)
- Usmarapride (memory)
- KW-6365
- Dihexa (low dose - recovery)
- bromantane
- CE-123 (modafinil analogue)
- methylphenidate (focus)
- Menthol (anxiolytic)
the list could go on
life is not a drug tested sport - if you dont enhance yourself your competition will and you will get left behind
Compounds: modafinil, cerebrolysin, crebinostat, piracetam, intranasal insulin, dextroamphetamine, pinealon, tropisetron, TAK-653, guanfacine, Chlorgyline, usmarapride, KW-6365, Dihexa, bromantane, CE-123, methylphenidate, menthol
running this interesting stack for the coming 4-8 weeks or so:
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
If you want autistic cognition without tweaking like you took some 99% Walter White special the stack would look something like:
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
think slower = more focus?
guanfacine does the exact OPPOSITE of a stimulant, it decreases firing in the prefrontal cortex instead of increasing it so that you dont electrocute like with modern stims
guanfacine also has other effects
increases BDNF
stops stressed neurons from dying
decreases dopamine release in VTA
suppresses cAMP production through α2A-AR signaling
restores dopaminergic tone over time
protects brain structure during hypoxia
decreases norepinephrine levels in prefrontal cortex
this basically makes it so you dont end up like electro, with a zapped out brain.
[Image shows Guanfacine Extended-Release Tablets medicine bottle with a movie still of blue-lit person]
1:07 AM · Apr 21, 2026 · 16.3K Views
Compounds: guanfacine
guanfacine does the exact OPPOSITE of a stimulant, it decreases firing in the prefrontal cortex instead of increasing it so that you dont electrocute like with modern stims
guanfacine also has other effects
increases BDNF
stops stressed neurons from dying
decreases dopamine release in VTA
suppresses cAMP production through α2A-AR signaling
restores dopaminergic tone over time
protects brain structure during hypoxia
decreases norepinephrine levels in prefrontal cortex
this basically makes it so you dont end up like electro, with a zapped out brain.
[Image shows Guanfacine Extended-Release Tablets medicine bottle with a movie still of blue-lit person]
1:07 AM · Apr 21, 2026 · 16.3K Views
Compounds: guanfacine
if you want focus + a drug-like high and don't care about the consequences take adderall
if you want focus + stimulation without the euphoria and comedown take modafinil
if you want just focus without stimulation take tak-653 or guanfacine
if you just want smooth focus remove all external dopamine from your life and take nicotine
[Image shows a large glowing eye with purple hues]
7:31 PM · May 4, 2026 · 18.2K Views
Compounds: adderall (amphetamine), modafinil, TAK-653, guanfacine, nicotine
if you want focus + stimulation without the euphoria and comedown take modafinil
if you want just focus without stimulation take tak-653 or guanfacine
if you just want smooth focus remove all external dopamine from your life and take nicotine
[Image shows a large glowing eye with purple hues]
7:31 PM · May 4, 2026 · 18.2K Views
Compounds: adderall (amphetamine), modafinil, TAK-653, guanfacine, nicotine