hCG (Human Chorionic Gonadotropin)
Category: hormones
Information Sheet
What It Is
hCG is a gonadotropin that mimics LH, stimulating testicular Leydig cells to produce testosterone; used in fertility, TRT and as a Leydig-cell stimulation test.
Mechanism & Notes
- Binds LH receptors on Leydig cells, driving endogenous testosterone production
- Used as a stimulation test of testicular reserve (e.g. vitamin-E steroidogenesis studies)
Mentions
Vitamin E megadosing nearly doubled testosterone in response to stimulation in clinical trial.
483 mg for 8 weeks rose baseline T by >100 points.
T rose from 415.5 → 609.2 ng/dl (↑1.47x) after hCG stimulation.
But with vitamin E? 552.7 → 1015.7 (↑1.85x)
hCG is a hormone that stimulates the testes to produce T.
If you've been eating seed oils most of your life - your tissues are likely starved for vitamin E, and this impairs cell signaling and structure at nearly every level.
[references the clinical trial: Umeda F et al., Effect of vitamin E on function of pituitary-gonadal axis in male rats and human subjects, Endocrinol Jpn 1982, PMID 6816576]
Compounds: vitamin E, hCG, testosterone
483 mg for 8 weeks rose baseline T by >100 points.
T rose from 415.5 → 609.2 ng/dl (↑1.47x) after hCG stimulation.
But with vitamin E? 552.7 → 1015.7 (↑1.85x)
hCG is a hormone that stimulates the testes to produce T.
If you've been eating seed oils most of your life - your tissues are likely starved for vitamin E, and this impairs cell signaling and structure at nearly every level.
[references the clinical trial: Umeda F et al., Effect of vitamin E on function of pituitary-gonadal axis in male rats and human subjects, Endocrinol Jpn 1982, PMID 6816576]
Compounds: vitamin E, hCG, testosterone
hCG stimulation of Leydig cells used to test testicular steroidogenic reserve; vitamin E supplementation markedly enhanced the hCG-stimulated testosterone response (1.85x vs 1.47x). PMID 6816576.
Compounds: hcg, vitamin e, testosterone
Compounds: hcg, vitamin e, testosterone