Intranasal Insulin
Category: peptides
Mentions
you can just take noots and stims and be smarter than everyone else
- modafinil (wakefulness + focus)
- cerebrolysin (recovery + cognition)
- crebinostat (literal photographic memory)
- piracetam
- IN insulin (cognition + recovery)
- dextroamphetamine (focus + memory)
- pinealon (recovery + sleep)
- tropisetron (calm focus)
- TAK-653
- guanfacine (non-stim)
- Chlorgyline (MAO-A)
- Usmarapride (memory)
- KW-6365
- Dihexa (low dose - recovery)
- bromantane
- CE-123 (modafinil analogue)
- methylphenidate (focus)
- Menthol (anxiolytic)
the list could go on
life is not a drug tested sport - if you dont enhance yourself your competition will and you will get left behind
Compounds: modafinil, cerebrolysin, crebinostat, piracetam, intranasal insulin, dextroamphetamine, pinealon, tropisetron, TAK-653, guanfacine, Chlorgyline, usmarapride, KW-6365, Dihexa, bromantane, CE-123, methylphenidate, menthol
- modafinil (wakefulness + focus)
- cerebrolysin (recovery + cognition)
- crebinostat (literal photographic memory)
- piracetam
- IN insulin (cognition + recovery)
- dextroamphetamine (focus + memory)
- pinealon (recovery + sleep)
- tropisetron (calm focus)
- TAK-653
- guanfacine (non-stim)
- Chlorgyline (MAO-A)
- Usmarapride (memory)
- KW-6365
- Dihexa (low dose - recovery)
- bromantane
- CE-123 (modafinil analogue)
- methylphenidate (focus)
- Menthol (anxiolytic)
the list could go on
life is not a drug tested sport - if you dont enhance yourself your competition will and you will get left behind
Compounds: modafinil, cerebrolysin, crebinostat, piracetam, intranasal insulin, dextroamphetamine, pinealon, tropisetron, TAK-653, guanfacine, Chlorgyline, usmarapride, KW-6365, Dihexa, bromantane, CE-123, methylphenidate, menthol
running this interesting stack for the coming 4-8 weeks or so:
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
morning
amantadine 100-200mg
royal jelly 5g
tadalafil 5mg
subq selanık 500mcg
epitalon 4mg
vilon 1mg
mexidol 250mg
ALCAR 500mg
mid-day/ afternoon
cerebrolysin 5ml (10 days)
agmatine sulfate 0.5g
evening
guanfacine 2-4mg
magnesium l-threonate 144mg
at need
intranasal insulin 20-60iu (non-modafinil days)
modafinil/armodafinil (100mg max)
NACET 50-100mg
citicoline 250mg
excluded supplements here as my current supp stack is weird to heal my broken foot.
trying something new here, focused on neuroprotection, dopaminergic and executive function optimization, glutamate mitigation, and systemic cellular longevity - not just acute (or even long-term) efficacy.
saving selegiline for the next experiments (the MAO inhibition is too limiting, it would be annoying)
not medical advice.
Compounds: amantadine, royal jelly, tadalafil, selanık (semax or selank), epitalon, vilon, mexidol (emoxypine), ALCAR, cerebrolysin, agmatine sulfate, guanfacine, magnesium l-threonate, intranasal insulin, modafinil, armodafinil, NACET, citicoline, selegiline
If you want autistic cognition without tweaking like you took some 99% Walter White special the stack would look something like:
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
Intranasal insulin 20IU
For removing distractions, improving memory formation and neuroprotection.
Dihexa 5mg
Potentiates memory formation even more, protects dopamine producing neurons and reduces neuro inflammation.
Guanfacine 1mg
Guanfacine is the opposite of a stimulant. It reduces firing in the prefrontal cortex which strengthens whatever firing happens making the connection stronger. Your brain is less noisy --> better cognition. Good for sleep and growth hormone as well. More BDNF. Restores dopaminergic signaling.
CDP-choline 300mg
Mitochondrial support, increases acetylcholine and citidine, increases dopamine and dopamine receptor density. Easy to get.
ISRIB 20mg
Makes sure anything related to stress does not negatively impact cognition without stimulating. Makes sure eLF2B gets activated which ensures memory formation and focus can stay dialed in.
Dialed in for the rest of the night.
Compounds: intranasal insulin, Dihexa, guanfacine, CDP-choline (citicoline), ISRIB
MScreenshot 2026-06-16 at 20.14.25.png.txt
https://x.com/doctormorphh/status/2046467515418617 (approx.)
At 28 you can literally learn anything you want and plasticity is thriving, especially the type of plasticity you need to learn new things.
if you want to improve plasticity:
Avoid smoking
Gut health
BPN14770
Pinealon
Magtein
ACD856
Bacopa monnieri
Intranasal Insulin
Learn new things constantly; languages, skills, chess, ...
Its important to combine all these tools with learning like the way one should combine steroids with training.
You will literally have child like learning again.
[Image shows Bradley Cooper as NZT48/Limitless movie character]
12:44 PM · Jun 10, 2026 · 23.7K Views
Compounds: BPN14770, pinealon, magtein (magnesium L-threonate), ACD856, Bacopa monnieri, intranasal insulin
At 28 you can literally learn anything you want and plasticity is thriving, especially the type of plasticity you need to learn new things.
if you want to improve plasticity:
Avoid smoking
Gut health
BPN14770
Pinealon
Magtein
ACD856
Bacopa monnieri
Intranasal Insulin
Learn new things constantly; languages, skills, chess, ...
Its important to combine all these tools with learning like the way one should combine steroids with training.
You will literally have child like learning again.
[Image shows Bradley Cooper as NZT48/Limitless movie character]
12:44 PM · Jun 10, 2026 · 23.7K Views
Compounds: BPN14770, pinealon, magtein (magnesium L-threonate), ACD856, Bacopa monnieri, intranasal insulin
MScreenshot 2026-06-17 at 21.47.40.png.txt
perfect mental enhancement stack for sleep deprivation: ISRIB, cerebrolysin, intranasal insulin, nebivolol, tak-653, magnesium-l-threonate
MScreenshot 2026-06-17 at 21.47.50.png.txt
stack that made researching a lot of fun: 3000mg Magtein, 40IU IN insulin, 5mg IN dihexa, 4mg TAK-653, 5g royal jelly, 200mg benfothiamine
when it comes to cognitive enhancement, it should start by enhancing glucose oxidation in the brain, and this should largely be obtained by following Peat's foundation.
but besides that, there are a ton of nootropics that have have enhanced brain glucose metabolism as one of their MOA's
actovegin, meldonium, cerebrolysin, intranasal insulin, mexidol (emoxypine succinate), bromantane/bemethyl come to mind
Compounds: actovegin, meldonium, cerebrolysin, intranasal insulin, mexidol (emoxypine succinate), bromantane/bemethyl
but besides that, there are a ton of nootropics that have have enhanced brain glucose metabolism as one of their MOA's
actovegin, meldonium, cerebrolysin, intranasal insulin, mexidol (emoxypine succinate), bromantane/bemethyl come to mind
Compounds: actovegin, meldonium, cerebrolysin, intranasal insulin, mexidol (emoxypine succinate), bromantane/bemethyl
[Also posted at https://x.com/aestheticprimal/status/2038649360976658450 — same thread]
Current Dopamine enhancement stack
extra fire to crush objectives (and actually chase the right objectives)
- 5mL Cerebrolysin (EOD)
- 2-4 IU Intranasal insulin (almost daily)
- 2g+ royal jelly (daily)
- 10-15mg 9-me-bc (daily)
below is why!👇
[reply] Cerebrolysin seems to enhance Dopaminergic transmission mainly through improving redox balance (total antioxidant capacity), and also seemingly through activation of GDNF receptor complex. Evidence on Cerebrolysin and Dopamine itself has not been studied much, but from personal experience the Dopamine baseline seems to be much much higher. when it comes to sourcing it, it's very different per region, Rupharma is decent, but even Indiamart is a better alternative.
[reply] Intranasal Insulin seems to be something very niche, until you realize that there's a tremendous amount of scientific literature on it, just go on google scholar and type in 'intranasal insulin' and you'll see. Seems to be mainly mediated through improving redox balance in the brain.
[reply] Royal Jelly does an amazing job at enhancing the burst firing of Dopaminergic neurons in the VTA (ventral tegmental area), through the connection of the VTA to the NAc (nucleus accumbens) it then enhances the desire to get stuff done.
[reply] 9-me-bc is one of the newer additions, and is perhaps the most potent tool for improving Dopaminergic transmission and getting that feeling of "I wanna get shit done today"; improves expression of enzymes required in Dopamine synthesis, improves total health of Dopaminergic neurons.
[related article] 9-me-bc - USE IT — 9-me-bc is an abbreviation for 9-methyl-beta-carboline... (see paper Polanski W et al., J Neurochem 2010, PMID 20374418)
Compounds: cerebrolysin, intranasal insulin, royal jelly, 9-me-bc (9-methyl-beta-carboline)
Current Dopamine enhancement stack
extra fire to crush objectives (and actually chase the right objectives)
- 5mL Cerebrolysin (EOD)
- 2-4 IU Intranasal insulin (almost daily)
- 2g+ royal jelly (daily)
- 10-15mg 9-me-bc (daily)
below is why!👇
[reply] Cerebrolysin seems to enhance Dopaminergic transmission mainly through improving redox balance (total antioxidant capacity), and also seemingly through activation of GDNF receptor complex. Evidence on Cerebrolysin and Dopamine itself has not been studied much, but from personal experience the Dopamine baseline seems to be much much higher. when it comes to sourcing it, it's very different per region, Rupharma is decent, but even Indiamart is a better alternative.
[reply] Intranasal Insulin seems to be something very niche, until you realize that there's a tremendous amount of scientific literature on it, just go on google scholar and type in 'intranasal insulin' and you'll see. Seems to be mainly mediated through improving redox balance in the brain.
[reply] Royal Jelly does an amazing job at enhancing the burst firing of Dopaminergic neurons in the VTA (ventral tegmental area), through the connection of the VTA to the NAc (nucleus accumbens) it then enhances the desire to get stuff done.
[reply] 9-me-bc is one of the newer additions, and is perhaps the most potent tool for improving Dopaminergic transmission and getting that feeling of "I wanna get shit done today"; improves expression of enzymes required in Dopamine synthesis, improves total health of Dopaminergic neurons.
[related article] 9-me-bc - USE IT — 9-me-bc is an abbreviation for 9-methyl-beta-carboline... (see paper Polanski W et al., J Neurochem 2010, PMID 20374418)
Compounds: cerebrolysin, intranasal insulin, royal jelly, 9-me-bc (9-methyl-beta-carboline)
Reading 100+ studies on the benefits of snorting insulin, these are all the ones i found:
METABOLIC EFFECTS
increases brain ATP
increases phosphocreatine
increases mitochondrial respiration
increases mitochondrial DNA markers (Nd1, Nd4)
increases antioxidant capacity
increases glutathione
increases SOD
activates Nrf2
lowers oxidative stress
lowers inflammatory signaling
lowers lactate:pyruvate ratio
stabilizes mitochondrial function
increases PGC-1α expression
increases cerebral blood flow
increases osteocalcin
glucose metabolism
increases GLUT-1 in stressed brains
preserves cerebral glucose metabolism in AD models
increases brain glucose levels
decreases brain glucose uptake in healthy lean men (state-dependent)
no change in peripheral glucose metabolism
no change in brain glucose levels (nuance)
improves neuronal metabolic efficiency
COGNITION
improves word recall
improves delayed memory recall
improves working memory
improves recognition memory
improves spatial learning
improves spatial navigation
improves learning speed
improves memory accuracy
improves memory in Alzheimer's
improves memory in people at risk of Alzheimer's
decreases cognitive decline
prevents anesthesia-induced learning impairment
improves exploration / curiosity behavior
increases motivation
lowers stress-induced weight loss
lowers corticosterone
improves cognition scores
improves long-term memory over months
NEUROPROTECTION
improves neuronal activity
improves neuronal connectivity
reduces Aβ plaque deposition
restores IRS-1 signaling
activates Akt survival signaling
restores mTOR signaling
restores brain insulin sensitivity
reduces neuronal degeneration
reduces brain injury markers
reduces stroke-induced neuronal loss
reduces brain swelling
repairs BBB integrity
increases survival after brain injury
reduces lesion size
reduces microglial activation
reduces inflammatory cytokines
reduces ER-stress apoptosis
reduces maladaptive autophagy
reduces caspase-3 positive neurons
prevents ATP depletion during excitotoxicity
prevents BDNF depletion during excitotoxicity
improves mitochondrial oxidative metabolism
reduces glutamate-induced excitotoxicity
NEUROTRANSMITTERS & NEUROTROPHIC FACTORS
decreases NET expression in locus coeruleus
increases DAT expression in VTA and substantia nigra
increases DAT-mediated dopamine reuptake
decreases dopamine levels in VTA via reuptake
restores adrenergic receptor signaling
restores serotonin receptor signaling
restores serotonin transporter levels (SERT)
increases BDNF
increases NGF-β
increases TrkB signaling
increases GDNF
increases NMDAR surface delivery
potentiates NMDA receptor currents
increases AMPAR endocytosis (GluR2-dependent)
activates PI3K-dependent synaptic plasticity
enhances hippocampal plasticity
increases GABA_A receptor activity
increases tonic GABA_A currents
restores inhibitory signaling during glutamate stress
increases presynaptic glutamate release in NAc
reduces glutamate excitation of dopamine neurons via endocannabinoids
changes dopaminergic midbrain connectivity
protects substantia nigra dopamine neurons
10/10?
Compounds: intranasal insulin
METABOLIC EFFECTS
increases brain ATP
increases phosphocreatine
increases mitochondrial respiration
increases mitochondrial DNA markers (Nd1, Nd4)
increases antioxidant capacity
increases glutathione
increases SOD
activates Nrf2
lowers oxidative stress
lowers inflammatory signaling
lowers lactate:pyruvate ratio
stabilizes mitochondrial function
increases PGC-1α expression
increases cerebral blood flow
increases osteocalcin
glucose metabolism
increases GLUT-1 in stressed brains
preserves cerebral glucose metabolism in AD models
increases brain glucose levels
decreases brain glucose uptake in healthy lean men (state-dependent)
no change in peripheral glucose metabolism
no change in brain glucose levels (nuance)
improves neuronal metabolic efficiency
COGNITION
improves word recall
improves delayed memory recall
improves working memory
improves recognition memory
improves spatial learning
improves spatial navigation
improves learning speed
improves memory accuracy
improves memory in Alzheimer's
improves memory in people at risk of Alzheimer's
decreases cognitive decline
prevents anesthesia-induced learning impairment
improves exploration / curiosity behavior
increases motivation
lowers stress-induced weight loss
lowers corticosterone
improves cognition scores
improves long-term memory over months
NEUROPROTECTION
improves neuronal activity
improves neuronal connectivity
reduces Aβ plaque deposition
restores IRS-1 signaling
activates Akt survival signaling
restores mTOR signaling
restores brain insulin sensitivity
reduces neuronal degeneration
reduces brain injury markers
reduces stroke-induced neuronal loss
reduces brain swelling
repairs BBB integrity
increases survival after brain injury
reduces lesion size
reduces microglial activation
reduces inflammatory cytokines
reduces ER-stress apoptosis
reduces maladaptive autophagy
reduces caspase-3 positive neurons
prevents ATP depletion during excitotoxicity
prevents BDNF depletion during excitotoxicity
improves mitochondrial oxidative metabolism
reduces glutamate-induced excitotoxicity
NEUROTRANSMITTERS & NEUROTROPHIC FACTORS
decreases NET expression in locus coeruleus
increases DAT expression in VTA and substantia nigra
increases DAT-mediated dopamine reuptake
decreases dopamine levels in VTA via reuptake
restores adrenergic receptor signaling
restores serotonin receptor signaling
restores serotonin transporter levels (SERT)
increases BDNF
increases NGF-β
increases TrkB signaling
increases GDNF
increases NMDAR surface delivery
potentiates NMDA receptor currents
increases AMPAR endocytosis (GluR2-dependent)
activates PI3K-dependent synaptic plasticity
enhances hippocampal plasticity
increases GABA_A receptor activity
increases tonic GABA_A currents
restores inhibitory signaling during glutamate stress
increases presynaptic glutamate release in NAc
reduces glutamate excitation of dopamine neurons via endocannabinoids
changes dopaminergic midbrain connectivity
protects substantia nigra dopamine neurons
10/10?
Compounds: intranasal insulin