Methylene Blue
Category: mitochondria
Information Sheet
What It Is
Methylene blue is a redox dye that acts as an alternative mitochondrial electron carrier, supporting ATP production and acting as a nootropic at low doses.
Mechanism & Notes
- Alternative electron carrier in the mitochondrial electron transport chain
- Low-dose nootropic/metabolic enhancer; discussed in a longevity context
Mentions
New longevity therapy started: cerebrolysin
What is cerebrolysin
Cerebrolysin is a mixture of peptides to enhance cognitive function. It fosters neuronal growth and repair which may improve memory. To date, cerebrolysin has been used to treat brain fog, brain injury, and slow down the process of dementia. Because a prior measurement indicated that I have swelling in my brain from my internal jugular vein stenosis (IJVS), we are examining the effectiveness of cerebrolysin in mitigating inflammation as well as any cognitive improvements.
Baseline measurements
After seeing my brain swelling via MRI from IJVS, we chose to proceed with cerebrolysin. We will be measuring the efficacy by monitoring brain MRI markers, sleeping HRV (3 month average at least, measured using WHOOP) and cognitive testing.
Strength of evidence
We find that the data on cerebrolysin in human clinical trials is promising. Most trials examine the effects of cerebrolysin on neurodegenerative diseases and the outcomes show consistent benefits in cognition and global clinical function. We cannot recommend that anyone else participates until more extensive clinical trials have been performed.
Protocol
Ten, 5 mL intramuscular injections over 20 days.
Cost: $160
What we expect to happen
We will be investigating several brain biomarkers to document the effects of cerebrolysin, specifically neurotrophic factors and markers of neural damage. MRI can be implemented to measure brain markers.
[reply] This is for pre symptomatic, long-term use, and want to avoid excessive IVs causing vein damage when it's not super clinically indicated.
[reply] no noticeable side effects, we'll know more with follow up measurement
[reply] BPC-157 is usually for injuries
[reply] it's not clear that methylene blue will add benefits over and above the basic that I'm already doing
Compounds: Cerebrolysin, BPC-157, methylene blue
What is cerebrolysin
Cerebrolysin is a mixture of peptides to enhance cognitive function. It fosters neuronal growth and repair which may improve memory. To date, cerebrolysin has been used to treat brain fog, brain injury, and slow down the process of dementia. Because a prior measurement indicated that I have swelling in my brain from my internal jugular vein stenosis (IJVS), we are examining the effectiveness of cerebrolysin in mitigating inflammation as well as any cognitive improvements.
Baseline measurements
After seeing my brain swelling via MRI from IJVS, we chose to proceed with cerebrolysin. We will be measuring the efficacy by monitoring brain MRI markers, sleeping HRV (3 month average at least, measured using WHOOP) and cognitive testing.
Strength of evidence
We find that the data on cerebrolysin in human clinical trials is promising. Most trials examine the effects of cerebrolysin on neurodegenerative diseases and the outcomes show consistent benefits in cognition and global clinical function. We cannot recommend that anyone else participates until more extensive clinical trials have been performed.
Protocol
Ten, 5 mL intramuscular injections over 20 days.
Cost: $160
What we expect to happen
We will be investigating several brain biomarkers to document the effects of cerebrolysin, specifically neurotrophic factors and markers of neural damage. MRI can be implemented to measure brain markers.
[reply] This is for pre symptomatic, long-term use, and want to avoid excessive IVs causing vein damage when it's not super clinically indicated.
[reply] no noticeable side effects, we'll know more with follow up measurement
[reply] BPC-157 is usually for injuries
[reply] it's not clear that methylene blue will add benefits over and above the basic that I'm already doing
Compounds: Cerebrolysin, BPC-157, methylene blue