Pregnenolone
Category: hormones
Mentions
Sodium butyrate raises testosterone via the LH/cAMP/PKA pathway in the Leydig cells of the testes.
By activating this pathway, butyrate upregulates the LH receptor, StAR, and CYP11A1 (the rate-limiting enzyme that converts cholesterol into pregnenolone).
Two studies:
1) Hyperuricemia model
Male mice with high uric acid were given 300 mg/kg/day of sodium butyrate for three weeks. It increased serum testosterone, sperm count, and motility, and activated the LH/cAMP/PKA pathway in their Leydig cells.
PMID: 40295597
2) Obesity model
Male mice made obese on a high-fat diet were given butyrate (5% of the diet) for 12 weeks. It increased testicular testosterone and restored sperm count and morphology while improving motility, by normalizing the testicular steroid-biosynthesis pathway.
PMID: 40226081
[Image shows a sodium butyrate supplement bottle and a testosterone level graph]
2:04 PM · Jun 10, 2026 · 1,441 Views
Compounds: sodium butyrate, pregnenolone, cholesterol
By activating this pathway, butyrate upregulates the LH receptor, StAR, and CYP11A1 (the rate-limiting enzyme that converts cholesterol into pregnenolone).
Two studies:
1) Hyperuricemia model
Male mice with high uric acid were given 300 mg/kg/day of sodium butyrate for three weeks. It increased serum testosterone, sperm count, and motility, and activated the LH/cAMP/PKA pathway in their Leydig cells.
PMID: 40295597
2) Obesity model
Male mice made obese on a high-fat diet were given butyrate (5% of the diet) for 12 weeks. It increased testicular testosterone and restored sperm count and morphology while improving motility, by normalizing the testicular steroid-biosynthesis pathway.
PMID: 40226081
[Image shows a sodium butyrate supplement bottle and a testosterone level graph]
2:04 PM · Jun 10, 2026 · 1,441 Views
Compounds: sodium butyrate, pregnenolone, cholesterol
BScreenshot 2026-06-17 at 21.47.45.png.txt
stuff i have coming in right now: bemethyl, tesofensine, BAM-15, dihexa, pregnenolone, thiamine TTFD, saltorexant, tak-653, vesugen, vilon, nsi-189, pri-8-53, gb-115, acd856, coluracetam
thousands of hours spent towards researching the enhancement of the performance of the brain, reading papers, and you basically just see how Peat his work come back in all of it.
Peat's fundamentals are key to follow when it comes to cognitive enhancement, almost anything that 'works' has a tremendous effect on glucose metabolism in the brain.
high carb/low fat diet
low iron and low PUFA (iron-dependent lipid-peroxidation is one of the main things that messes up (brain) redox status
thyroid running fast for even further enhanced glucose metabolism
anti-learned helplessness thinking
preventing stress cascades from excessive phosphate (PTH), low-sodium (RAAS)
neurosteroids downstream from Pregnenolone, or Pregnenolone itself (which is also a neurosteroid)
Bohr effect from enhanced Co2 retention/production
the gut-liver-brain axis (limit endotoxin, negative gram bacteria, preventing bacterial overgrowth)
amino acid balance, limiting methionine, cysteine, tryptophan
keeping serotonin at bay (antagonism of most 5-HTr's, like 5-HT6r increases activity in most parts of the PFC)
b-vitamins their role in the Krebs cycle, especially Thiamine through PDH
ultimately it is the true foundation of cognitive enhancement
[reply] acetylcholine itself seems to be pro-cognitive
[reply] have u read Peat his articles about DHA?
Compounds: pregnenolone, thiamine (B1), iron (low), methionine, cysteine, tryptophan, DHA/PUFA
Peat's fundamentals are key to follow when it comes to cognitive enhancement, almost anything that 'works' has a tremendous effect on glucose metabolism in the brain.
high carb/low fat diet
low iron and low PUFA (iron-dependent lipid-peroxidation is one of the main things that messes up (brain) redox status
thyroid running fast for even further enhanced glucose metabolism
anti-learned helplessness thinking
preventing stress cascades from excessive phosphate (PTH), low-sodium (RAAS)
neurosteroids downstream from Pregnenolone, or Pregnenolone itself (which is also a neurosteroid)
Bohr effect from enhanced Co2 retention/production
the gut-liver-brain axis (limit endotoxin, negative gram bacteria, preventing bacterial overgrowth)
amino acid balance, limiting methionine, cysteine, tryptophan
keeping serotonin at bay (antagonism of most 5-HTr's, like 5-HT6r increases activity in most parts of the PFC)
b-vitamins their role in the Krebs cycle, especially Thiamine through PDH
ultimately it is the true foundation of cognitive enhancement
[reply] acetylcholine itself seems to be pro-cognitive
[reply] have u read Peat his articles about DHA?
Compounds: pregnenolone, thiamine (B1), iron (low), methionine, cysteine, tryptophan, DHA/PUFA